Cav1^tm1Pesch
Targeted Allele Detail

Summary

• Symbol: Cav1^tm1Pesch
• Name: caveolin 1, caveolae protein; targeted mutation 1, Philipp E Scherer
• MGI ID: MGI:5316847
• Gene: Cav1 Location: Chr6:17306387-17341323 bp, + strand Genetic Position: Chr6, 7.73 cM, cytoband A2
• Alliance: Cav1^tm1Pesch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182288
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 3 and a loxP site was inserted in exon 3 via homologous recombination. (J:182288)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cav1 Mutation: 31 strains or lines available

References

• Original: J:182288 Asterholm IW, et al., Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1. Cell Metab. 2012 Feb 8;15(2):171-85
• All: 4 reference(s)