Eya1^tm2Px
Targeted Allele Detail

Summary

• Symbol: Eya1^tm2Px
• Name: EYA transcriptional coactivator and phosphatase 1; targeted mutation 2, Pin-Xian Xu
• MGI ID: MGI:5316865
• Synonyms: Eya1^flox
• Gene: Eya1 Location: Chr1:14239178-14380459 bp, - strand Genetic Position: Chr1, 4.31 cM
• Alliance: Eya1^tm2Px page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181471
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector was designed to insert a loxP site upstream of exon 1 and a second loxP site, downstream of exon 1 of the EYA transcriptional coactivator and phosphatase 1 (Eya1) gene, followed by an FRT-flanked neomycin selection cassette. Flp-recombinase removed neomycin cassette. (J:181471)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eya1 Mutation: 56 strains or lines available

References

• Original: J:181471 Ahmed M, et al., Eya1-six1 interaction is sufficient to induce hair cell fate in the cochlea by activating atoh1 expression in cooperation with sox2. Dev Cell. 2012 Feb 14;22(2):377-90
• All: 3 reference(s)