Tg(tetO-ATXN1*82Q)#Horr
Transgene Detail

Summary

• Symbol: Tg(tetO-ATXN1*82Q)#Horr
• Name: transgene insertion, Harry T Orr
• MGI ID: MGI:5317077
• Synonyms: condSCA1[82Q], TRE-SCA1[82Q]
• Transgene: Tg(tetO-ATXN1*82Q)#Horr Location: unknown
• Alliance: Tg(tetO-ATXN1*82Q)#Horr page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-ATXN1*82Q)#Horr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATXN1 (6310)

  Atxn1

  (MGI:104783)

• Mutation details: This transgene consists of the human ATXN1 (SCA1) cDNA encoding a mutant polyglutamine tract with 82 repeats joined to the TRE element. Seven founders were generated and the pound symbol (#) is used when a line is not specified and/or lines are pooled. (J:95453)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:95453 Zu T, et al., Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice. J Neurosci. 2004 Oct 6;24(40):8853-61
• All: 6 reference(s)