Del(5Gtf2i-Limk1)1Uta
Targeted Allele Detail

Summary

• Symbol: Del(5Gtf2i-Limk1)1Uta
• Name: deletion, Chr 5, Uta Francke 1
• MGI ID: MGI:5317120
• Synonyms: Del1Uta, PD
• Gene: Del(5Gtf2i-Limk1)1Uta Location: Chr5:134266688-134717452 bp Genetic Position: Chr5, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182796
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(5Gtf2i-Limk1)1Uta involves 15 genes/genome features (Gm26340, n-R5s178, Gtf2i ...) View all
• Mutation details: Cre-mediated recombination of mice carrying Gtf2i^tm1Uta and Limk1^tm2Uta removed all genomic sequence between the two alleles (including Gtf2i, Gtf2ird1, Clip2, Syna, Rfc2 Lat2, Eif4h and Limk1). (J:182796)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(5Gtf2i-Limk1)1Uta Mutation: 1 strain or line available

References

• Original: J:182796 Li HH, et al., Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice. EMBO Mol Med. 2009 Apr;1(1):50-65
• All: 5 reference(s)