Del(5Limk1-Trim50)2Uta
Targeted Allele Detail

Summary

• Symbol: Del(5Limk1-Trim50)2Uta
• Name: deletion, Chr 5, Uta Francke 2
• MGI ID: MGI:5317121
• Synonyms: DD, Del2Uta
• Gene: Del(5Limk1-Trim50)2Uta Location: Chr5:134684893-135396859 bp Genetic Position: Chr5, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182796
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(5Limk1-Trim50)2Uta involves 28 genes/genome features (Gm25315, Limk1, Gm10369 ...) View all
• Mutation details: Cre-mediated recombination of ES cells carrying Limk1^tm1Uta and Trim50^tm1Uta removed all genomic sequence between the two alleles (including Limk1, Eln, Wbscr26, Cldn13, Wbscr27, Cldn4, Cldn3, Abhd11, Stx1a, Wbscr22, Wbscr18, Vps37d, Mlxipl, Tbl2, Bcl7b, Baz1b, Fzd9, Fkbp6 and Trim50). (J:182796)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(5Limk1-Trim50)2Uta Mutation: 1 strain or line available

References

• Original: J:182796 Li HH, et al., Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice. EMBO Mol Med. 2009 Apr;1(1):50-65
• All: 4 reference(s)