Gjc1^{tm1.1(Gjd2)Kwi}
Targeted Allele Detail

Summary

• Symbol: Gjc1^{tm1.1(Gjd2)Kwi}
• Name: gap junction protein, gamma 1; targeted mutation 1.1, Klaus Willecke
• MGI ID: MGI:5317162
• Synonyms: Cx45^fl(Cx36)
• Gene: Gjc1 Location: Chr11:102690405-102710526 bp, - strand Genetic Position: Chr11, 66.48 cM
• Alliance: Gjc1^{tm1.1(Gjd2)Kwi} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182927
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. A construct containing an FRT-flanked neo cassette, loxP site, mouse cDNA, IRES, and nuclear localized lacZ was placed downstream of exon 3. Flp-mediated recombination removed the neo cassette. (J:182927)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gjc1 Mutation: 33 strains or lines available

References

• Original: J:182927 Frank M, et al., Neuronal connexin-36 can functionally replace connexin-45 in mouse retina but not in the developing heart. J Cell Sci. 2010 Oct 15;123(Pt 20):3605-15
• All: 1 reference(s)