Crim1^{tm1(GFP/cre/ERT2)Pzg}
Targeted Allele Detail

Summary

• Symbol: Crim1^{tm1(GFP/cre/ERT2)Pzg}
• Name: cysteine rich transmembrane BMP regulator 1; targeted mutation 1, Pumin Zhang
• MGI ID: MGI:5317218
• Synonyms: Crim1-GCE
• Gene: Crim1 Location: Chr17:78507677-78684021 bp, + strand Genetic Position: Chr17, 48.09 cM
• Alliance: Crim1^{tm1(GFP/cre/ERT2)Pzg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159099
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Crim1^{tm1(GFP/cre/ERT2)Pzg} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Crim1 (MGI:1354756)

• Mutation details: A targeting vector containing GFP-Cre/ERT2 cassette (GCE) and FRT site flanked Kanamycin/neomycin selection cassette was used to disrupt the exon containing the ATG translation start-site. The construct was electroporated into 129S7/SvEvBrd-Hprt1b-m2 derived AB2.2 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipientblastocysts. The resulting chimeric animals were crossed to C57BL/6 mice. (J:159099)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Crim1 (mouse) Summary of all recombinase alleles driven by Crim1. Alliance mouse Crim1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crim1 Mutation: 52 strains or lines available

References

• Original: J:159099 McMahon A, et al., Summary of mouse strains characterized by GUDMAP consortium. Unpublished. 2010
• All: 4 reference(s)