Ifng^tm3.1Lky
Targeted Allele Detail

Summary

• Symbol: Ifng^tm3.1Lky
• Name: interferon gamma; targeted mutation 3.1, Richard M Locksley
• MGI ID: MGI:5317415
• Synonyms: GREAT, Ifng^tm3(EYFP)Lky
• Gene: Ifng Location: Chr10:118276951-118281797 bp, + strand Genetic Position: Chr10, 66.75 cM
• Alliance: Ifng^tm3.1Lky page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147784
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted (No functional change, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector was designed with a loxP-flanked neomycin resistance cassette, an internal ribosome entry site (IRES), and an enhanced yellow fluorescent protein (eYFP) sequence. This vector was inserted downstream of the endogenous translational stop codon and upstream of the 3' untranslated region (UTR). Cre-mediated recombination removed the neo cassette. (J:147784)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ifng Mutation: 49 strains or lines available

References

• Original: J:147784 Reinhardt RL, et al., Cytokine-secreting follicular T cells shape the antibody repertoire. Nat Immunol. 2009 Apr;10(4):385-93
• All: 94 reference(s)