Hmgn5^tm1.1Mbus
Targeted Allele Detail

Summary

• Symbol: Hmgn5^tm1.1Mbus
• Name: high-mobility group nucleosome binding domain 5; targeted mutation 1.1, Michael Bustin
• MGI ID: MGI:5317454
• Gene: Hmgn5 Location: ChrX:108048143-108056986 bp, - strand Genetic Position: ChrX, 47.92 cM
• Alliance: Hmgn5^tm1.1Mbus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182874
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette and a loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the neo cassette and left exons 2 through 4 floxed. (J:185263)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hmgn5 Mutation: 3 strains or lines available

References

• Original: J:182874 Rochman M, et al., Effects of HMGN variants on the cellular transcription profile. Nucleic Acids Res. 2011 May;39(10):4076-87
• All: 2 reference(s)