Tg(Igh-Mir155)10Cro
Transgene Detail

Summary

• Symbol: Tg(Igh-Mir155)10Cro
• Name: transgene insertion 10, Carlo M Croce
• MGI ID: MGI:5317461
• Synonyms: Emu-miR155
• Transgene: Tg(Igh-Mir155)10Cro Location: unknown
• Alliance: Tg(Igh-Mir155)10Cro page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igh-Mir155)10Cro expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mir155 (MGI:2676840)

• Mutation details: The Emu enhancer and Igh promoter drives late pro-B cell-specific expression of the mouse microRNA followed by the 3'UTR and polyadenylation sequence from the human beta-globin gene. Eight founders were established generating several lines (lines 8 through 15). Northern blot analysis confirmed transcript expression in the spleen. (J:109591)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:109591 Costinean S, et al., Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc Natl Acad Sci U S A. 2006 May 2;103(18):7024-9
• All: 1 reference(s)