b2b827Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b827Clo
• Name: Mutant line 827; Bench to Bassinet Program (B2B/CVDC), mutation 827 Cecilia Lo
• MGI ID: MGI:5317766
• Gene: b2b827Clo Location: unknown
• Alliance: b2b827Clo page

Micrognathia observed in mutant 827-004-LA

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• This ENU-induced mutation was isolated in a screen at the University of Pittsburgh.

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any b2b827Clo Mutation: 1 strain or line available

Notes

Summative Diagnosis:
Cardiac defect phenotype: Left ventricular hypertrophy and perimembranous (pm)/muscular (m) ventricular septal defect (VSD)
Non-cardiovascular defects: Cleft palate, cleft lip, micrognathia, and anophthalmia

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
1300	Ventricular septal defect
3608	Left ventricular hypertrophy
3804	Congenital heart disease
4163	Micrognathia
4401	Cleft palate and cleft lip
4864	Anophthalmia

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 2 reference(s)