Rit1^tm1Dand
Targeted Allele Detail

Summary

• Symbol: Rit1^tm1Dand
• Name: Ras-like without CAAX 1; targeted mutation 1, Douglas A Andres
• MGI ID: MGI:5317831
• Gene: Rit1 Location: Chr3:88624154-88638354 bp, + strand Genetic Position: Chr3, 38.95 cM, cytoband F1
• Alliance: Rit1^tm1Dand page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183038
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding sequence of exon 2 was replaced with a lacZ gene and FRT-flanked neo cassette. RT-PCR confirmed the absence of transcript expression in embryonic fibroblasts. (J:183038)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rit1 Mutation: 18 strains or lines available

References

• Original: J:183038 Cai W, et al., An evolutionarily conserved Rit GTPase-p38 MAPK signaling pathway mediates oxidative stress resistance. Mol Biol Cell. 2011 Sep;22(17):3231-41
• All: 3 reference(s)