Sgk1^tm1.1Palm
Targeted Allele Detail

Summary

• Symbol: Sgk1^tm1.1Palm
• Name: serum/glucocorticoid regulated kinase 1; targeted mutation 1, Lawrence G Palmer
• MGI ID: MGI:5317845
• Synonyms: Sgk1^flox
• Gene: Sgk1 Location: Chr10:21758083-21875802 bp, + strand Genetic Position: Chr10, 9.83 cM, cytoband A3
• Alliance: Sgk1^tm1.1Palm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148648
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into the BsaHI site in intron 1, and a loxP site and a FRT-flanked neomycin cassette was inserted into the XcmI site in intron 6. Flp-mediated recombination removed the neo cassette. (J:148648)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sgk1 Mutation: 151 strains or lines available

Notes

Embryonic stem cell line described as R1129/Sv x 129/Sv-CP

References

• Original: J:148648 Fejes-Toth G, et al., Epithelial Na+ channel activation and processing in mice lacking SGK1. Am J Physiol Renal Physiol. 2008 Jun;294(6):F1298-305
• All: 16 reference(s)