Pax6tm1.1Xzh
Targeted Allele Detail
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Symbol: |
Pax6tm1.1Xzh |
Name: |
paired box 6; targeted mutation 1.1, Xin Zhang |
MGI ID: |
MGI:5317866 |
Synonyms: |
Pax6deltaPE |
Gene: |
Pax6 Location: Chr2:105499245-105527709 bp, + strand Genetic Position: Chr2, 55.31 cM
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Alliance: |
Pax6tm1.1Xzh page
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Germline Transmission: |
Earliest citation of germline transmission:
J:182769
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Conditional ready, Modified regulatory region, No functional change) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site and an Sph I site were inserted upstream of the distal enhancer element and the 450 bp proximal enhancer element was replaced with an FRT flanked neo cassette and a loxP site. Flp-mediated recombination removed the neo cassette. RT-PCR analysis indicates reduced pancreatic expression in homozygous mice at E15.5.
(J:182769)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pax6 Mutation: |
94 strains or lines available
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Original: |
J:182769 Carbe C, et al., The functional role of the Meis/Prep-binding elements in Pax6 locus during pancreas and eye development. Dev Biol. 2012 Mar 1;363(1):320-9 |
All: |
1 reference(s) |
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