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Pax6tm1.1Xzh
Targeted Allele Detail
Summary
Symbol: Pax6tm1.1Xzh
Name: paired box 6; targeted mutation 1.1, Xin Zhang
MGI ID: MGI:5317866
Synonyms: Pax6deltaPE
Gene: Pax6  Location: Chr2:105499245-105527709 bp, + strand  Genetic Position: Chr2, 55.31 cM
Alliance: Pax6tm1.1Xzh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:182769
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, Modified regulatory region, No functional change)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site and an Sph I site were inserted upstream of the distal enhancer element and the 450 bp proximal enhancer element was replaced with an FRT flanked neo cassette and a loxP site. Flp-mediated recombination removed the neo cassette. RT-PCR analysis indicates reduced pancreatic expression in homozygous mice at E15.5. (J:182769)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pax6 Mutation:  94 strains or lines available
References
Original:  J:182769 Carbe C, et al., The functional role of the Meis/Prep-binding elements in Pax6 locus during pancreas and eye development. Dev Biol. 2012 Mar 1;363(1):320-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory