Pax6^tm1.2Xzh
Targeted Allele Detail

Summary

• Symbol: Pax6^tm1.2Xzh
• Name: paired box 6; targeted mutation 1.2, Xin Zhang
• MGI ID: MGI:5317867
• Synonyms: Pax6^deltaDP
• Gene: Pax6 Location: Chr2:105499245-105527709 bp, + strand Genetic Position: Chr2, 55.31 cM
• Alliance: Pax6^tm1.2Xzh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182769
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Hypomorph, Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and an Sph I site were inserted upstream of the distal enhancer element and the 450 bp proximal enhancer element was replaced with an FRT flanked neo cassette and a loxP site. Recombinase mediated recombination removed the neo cassette and a 3.1 kb region including the distal and the ectodermal enhancer elements. RT-PCR analysis indicates reduced pancreatic expression in homozygous mice at E15.5. (J:182769)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax6 Mutation: 94 strains or lines available

References

• Original: J:182769 Carbe C, et al., The functional role of the Meis/Prep-binding elements in Pax6 locus during pancreas and eye development. Dev Biol. 2012 Mar 1;363(1):320-9
• All: 1 reference(s)