Pknox1^tm1.1Xzh
Targeted Allele Detail

Summary

• Symbol: Pknox1^tm1.1Xzh
• Name: Pbx/knotted 1 homeobox; targeted mutation 1.1, Xin Zhang
• MGI ID: MGI:5317868
• Synonyms: Prep1^flox
• Gene: Pknox1 Location: Chr17:31783708-31826667 bp, + strand Genetic Position: Chr17, 16.78 cM, cytoband B-C
• Alliance: Pknox1^tm1.1Xzh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182769
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 8 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 8 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 8 floxed. (J:182769)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pknox1 Mutation: 90 strains or lines available

References

• Original: J:182769 Carbe C, et al., The functional role of the Meis/Prep-binding elements in Pax6 locus during pancreas and eye development. Dev Biol. 2012 Mar 1;363(1):320-9
• All: 1 reference(s)