About   Help   FAQ
Pknox1tm1.2Xzh
Targeted Allele Detail
Summary
Symbol: Pknox1tm1.2Xzh
Name: Pbx/knotted 1 homeobox; targeted mutation 1.2, Xin Zhang
MGI ID: MGI:5317869
Synonyms: Prep1delta
Gene: Pknox1  Location: Chr17:31783708-31826667 bp, + strand  Genetic Position: Chr17, 16.78 cM, cytoband B-C
Alliance: Pknox1tm1.2Xzh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:182769
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 8 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 8 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exon 8. Western blot analysis detected the presence of a truncated protein. (J:182769)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pknox1 Mutation:  90 strains or lines available
References
Original:  J:182769 Carbe C, et al., The functional role of the Meis/Prep-binding elements in Pax6 locus during pancreas and eye development. Dev Biol. 2012 Mar 1;363(1):320-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/22/2024
MGI 6.24
The Jackson Laboratory