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Pknox1tm1.2Xzh
Targeted Allele Detail
Summary
Symbol: Pknox1tm1.2Xzh
Name: Pbx/knotted 1 homeobox; targeted mutation 1.2, Xin Zhang
MGI ID: MGI:5317869
Synonyms: Prep1delta
Gene: Pknox1  Location: Chr17:31783708-31826667 bp, + strand  Genetic Position: Chr17, 16.78 cM, cytoband B-C
Alliance: Pknox1tm1.2Xzh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:182769
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 8 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 8 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exon 8. Western blot analysis detected the presence of a truncated protein. (J:182769)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pknox1 Mutation:  90 strains or lines available
References
Original:  J:182769 Carbe C, et al., The functional role of the Meis/Prep-binding elements in Pax6 locus during pancreas and eye development. Dev Biol. 2012 Mar 1;363(1):320-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory