Akt1^tm2.1Mbb
Targeted Allele Detail

Summary

• Symbol: Akt1^tm2.1Mbb
• Name: thymoma viral proto-oncogene 1; targeted mutation 2.1, Morris J Birnbaum
• MGI ID: MGI:5317890
• Gene: Akt1 Location: Chr12:112620260-112641266 bp, - strand Genetic Position: Chr12, 61.2 cM, cytoband F1-F2
• Alliance: Akt1^tm2.1Mbb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182721
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exons 3 and 4. Western blot analysis confirmed the absence of protein expression. (J:182721)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akt1 Mutation: 34 strains or lines available

References

• Original: J:182721 Wan M, et al., Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity. Mol Cell Biol. 2012 Jan;32(1):96-106
• All: 1 reference(s)