Noto^{tm2.1(Foxj1)Gos}
Targeted Allele Detail

Summary

• Symbol: Noto^{tm2.1(Foxj1)Gos}
• Name: notochord homeobox; targeted mutation 2.1, Achim Gossler
• MGI ID: MGI:5317920
• Synonyms: Noto^Foxj1
• Gene: Noto Location: Chr6:85400868-85405859 bp, + strand Genetic Position: Chr6, 37.44 cM
• Alliance: Noto^{tm2.1(Foxj1)Gos} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182741
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 1 and all of exon 2 were replaced with the coding sequence for Foxj1, an IRES2-tdtomato, and an FRT flanked neo cassette. Flp mediated recombination removed the neo cassette. Expression of tdtomato is detected in the node in heterozygous embryos. Expression of Foxj1 mRNA is detected in homozygous embryos at E7.5-8. (J:182741)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Noto Mutation: 15 strains or lines available

References

• Original: J:182741 Alten L, et al., Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1. Development. 2012 Apr;139(7):1276-84
• All: 2 reference(s)