Klf10^tm1Wkle
Targeted Allele Detail

Summary

• Symbol: Klf10^tm1Wkle
• Name: Kruppel-like transcription factor 10; targeted mutation 1, Woon Kyu Lee
• MGI ID: MGI:5317944
• Gene: Klf10 Location: Chr15:38291707-38300950 bp, - strand Genetic Position: Chr15, 15.15 cM
• Alliance: Klf10^tm1Wkle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182595
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced all of exons 1 and 2 and part of exon 3. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts, brain, kidney and liver. (J:182595)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf10 Mutation: 26 strains or lines available

References

• Original: J:182595 Song KD, et al., KLF10, transforming growth factor-beta-inducible early gene 1, acts as a tumor suppressor. Biochem Biophys Res Commun. 2012 Mar 9;419(2):388-94
• All: 6 reference(s)