Wnk3^tm1.1Esoh
Targeted Allele Detail

Summary

• Symbol: Wnk3^tm1.1Esoh
• Name: WNK lysine deficient protein kinase 3; targeted mutation 1.1, Eisei Sohara
• MGI ID: MGI:5318041
• Gene: Wnk3 Location: ChrX:149981074-150103148 bp, + strand Genetic Position: ChrX, 68.46 cM
• Alliance: Wnk3^tm1.1Esoh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181538
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the neo cassette. Western blot analysis confirmed the absence of protein expression in the brain, kidney and testis. (J:181538)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnk3 Mutation: 14 strains or lines available

References

• Original: J:181538 Oi K, et al., A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo. Biol Open. 2012;1:120-127
• All: 1 reference(s)