Braf^tm1Tuv
Targeted Allele Detail

Summary

• Symbol: Braf^tm1Tuv
• Name: Braf transforming gene; targeted mutation 1, David A Tuveson
• MGI ID: MGI:5318063
• Synonyms: LSL-B-Raf^V619E
• Gene: Braf Location: Chr6:39580171-39702397 bp, - strand Genetic Position: Chr6, 18.43 cM
• Alliance: Braf^tm1Tuv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177503
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Single point mutation
• Mutation details: A floxed STOP cassette blocks expression of a modified gene in which nucleotide substitution results in the amino acid substitution of glutamic acid for valine at position 619 (V619E). (J:177503)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Braf Mutation: 60 strains or lines available

References

• Original: J:177503 Karreth FA, et al., In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma. Cell. 2011 Oct 14;147(2):382-95
• All: 3 reference(s)