Cdk1^tm2.1Kald
Targeted Allele Detail

Summary

• Symbol: Cdk1^tm2.1Kald
• Name: cyclin dependent kinase 1; targeted mutation 2.1, Philipp Kaldis
• MGI ID: MGI:5318085
• Synonyms: Cdk1^FLOX
• Gene: Cdk1 Location: Chr10:69170976-69188742 bp, - strand Genetic Position: Chr10, 36.07 cM
• Alliance: Cdk1^tm2.1Kald page

Livers of Cdk1^tm2.1Kald/Cdk1^tm2.1Kald Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice conatin fewer hepatocytes

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182141
• Parent Cell Line: S1B6 (ES Cell)
• Strain of Origin: 129S1/SvImJ or C57BL/6J

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette and left exon 3 floxed. (J:182141)

Generation of the floxed Cdk1^tm2.1Kald and knock-out Cdk1^tm2.2Kald alleles

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk1 Mutation: 21 strains or lines available

References

• Original: J:182141 Diril MK, et al., Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3826-31
• All: 13 reference(s)