Kcnk1^tm1.1Barh
Targeted Allele Detail

Summary

• Symbol: Kcnk1^tm1.1Barh
• Name: potassium channel, subfamily K, member 1; targeted mutation 1.1, Jacques Barhanin
• MGI ID: MGI:5318213
• Synonyms: TWIK-1^-
• Gene: Kcnk1 Location: Chr8:126721909-126757424 bp, + strand Genetic Position: Chr8, 73.67 cM
• Alliance: Kcnk1^tm1.1Barh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183234
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and a floxed pgk-neo cassette was inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed exon 2 and the neo cassette. (J:183234)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcnk1 Mutation: 29 strains or lines available

References

• Original: J:183234 Nie X, et al., Expression and insights on function of potassium channel TWIK-1 in mouse kidney. Pflugers Arch. 2005 Dec;451(3):479-88
• All: 5 reference(s)