Stab2^tm1Ami
Targeted Allele Detail

Summary

• Symbol: Stab2^tm1Ami
• Name: stabilin 2; targeted mutation 1, Atsushi Miyajima
• MGI ID: MGI:5318244
• Gene: Stab2 Location: Chr10:86677062-86843889 bp, - strand Genetic Position: Chr10, 43.14 cM
• Alliance: Stab2^tm1Ami page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182239
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Genomic sequence including most of exon 1 and part of intron 1 was replaced with a lacZ and neo expressing cassette via homologous recombination. RT-PCR and immunostaining confirmed the absence of expression in homozygous mice. (J:182239)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stab2 Mutation: 138 strains or lines available

References

• Original: J:182239 Hirose Y, et al., Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4263-8
• All: 3 reference(s)