b2b972Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b972Clo
• Name: Mutant line 972; Bench to Bassinet Program (B2B/CVDC), mutation 972 Cecilia Lo
• MGI ID: MGI:5318330
• Gene: b2b972Clo Location: unknown
• Alliance: b2b972Clo page

Mutant 972-004-1 (E17.5) exhibits mesocardia with interrupted arotic arch

Show the 13 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• This ENU-induced mutation was isolated in a screen at the University of Pittsburgh.

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any b2b972Clo Mutation: 1 strain or line available

Notes

Summative Diagnosis:
Double outlet right ventricle (DORV) with subaortic ventricular septal defect (VSD), non-compaction of right ventricle (RV), and aortic arch anomalies including interrupted aortic arch (IAA)

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
0600	Double outlet right ventricle
1250	Interrupted aortic arch
1300	Ventricular septal defect
1802	Excessive myocardial trabeculation or noncompaction
2700	Abnormal aortic arch
3804	Congenital heart disease

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 2 reference(s)