b2b977Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b977Clo
• Name: Mutant line 977; Bench to Bassinet Program (B2B/CVDC), mutation 227 Cecilia Lo
• MGI ID: MGI:5318333
• Gene: b2b977Clo Location: unknown
• Alliance: b2b977Clo page

Transposition of the great arteries (TGA) confirmed by EFIC imaging in mutant 977-007-1 (E17.5)

Show the 9 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. (J:175213)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any b2b977Clo Mutation: 1 strain or line available

Notes

Summative Diagnosis:
Double outlet right ventricle (DORV), transposition of the great arteries (TGA), myocardial non-compaction and aortic arch anomalies including interrupted aortic arch (IAA) and right aortic arch (RAA)

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
0600	Double outlet right ventricle
0700	D-loop transposition of the great arteries
1250	Interrupted aortic arch
1802	Excessive myocardial trabeculation or noncompaction
2700	Abnormal aortic arch
3804	Congenital heart disease

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 2 reference(s)