Ltbr^tm1.1Thhe
Targeted Allele Detail

Summary

• Symbol: Ltbr^tm1.1Thhe
• Name: lymphotoxin B receptor; targeted mutation 1.1, Thomas Hehlgans
• MGI ID: MGI:5318395
• Synonyms: LTbetaR^flox
• Gene: Ltbr Location: Chr6:125283534-125290848 bp, - strand Genetic Position: Chr6, 59.32 cM
• Alliance: Ltbr^tm1.1Thhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183109
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 10. Flp-mediated recombination removed the neo cassette. (J:183109)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ltbr Mutation: 47 strains or lines available

References

• Original: J:183109 Wimmer N, et al., Lymphotoxin beta receptor activation on macrophages induces cross-tolerance to TLR4 and TLR9 ligands. J Immunol. 2012 Apr 1;188(7):3426-33
• All: 19 reference(s)