Epcam^tm1.1Mcu
Targeted Allele Detail

Summary

• Symbol: Epcam^tm1.1Mcu
• Name: epithelial cell adhesion molecule; targeted mutation 1.1, Mark C Udey
• MGI ID: MGI:5318399
• Synonyms: EpCAM^fl
• Gene: Epcam Location: Chr17:87943407-87958555 bp, + strand Genetic Position: Chr17, 57.87 cM
• Alliance: Epcam^tm1.1Mcu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182665
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6 x 129)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 200 bp upstream of exon 1 and a floxed and FRT flanked neo cassette was inserted 600 bp downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:182665)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epcam Mutation: 33 strains or lines available

References

• Original: J:182665 Gaiser MR, et al., Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo. Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):E889-97
• All: 3 reference(s)