Sulf2^tm1Mmas
Targeted Allele Detail

Summary

• Symbol: Sulf2^tm1Mmas
• Name: sulfatase 2; targeted mutation 1, Masayuki Masu
• MGI ID: MGI:5318490
• Gene: Sulf2 Location: Chr2:165915819-165997603 bp, - strand Genetic Position: Chr2, 86.31 cM, cytoband H3
• Alliance: Sulf2^tm1Mmas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183277
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: Exon 5 was replaced with an IRES-lacZ and neo cassette. Northern blot analysis confirmed the absence of transcript expression. (J:183277)

Generation of the Sulf2^tm1Mmas allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sulf2 Mutation: 177 strains or lines available

References

• Original: J:183277 Nagamine S, et al., Organ-specific sulfation patterns of heparan sulfate generated by extracellular sulfatases Sulf1 and Sulf2 in mice. J Biol Chem. 2012 Mar 16;287(12):9579-90
• All: 8 reference(s)