Tamalin^tm1.1Tes
Targeted Allele Detail

Summary

• Symbol: Tamalin^tm1.1Tes
• Name: trafficking regulator and scaffold protein tamalin; targeted mutation 1.1, Lino Tessarollo
• MGI ID: MGI:5318549
• Gene: Tamalin Location: Chr15:101122088-101130637 bp, + strand Genetic Position: Chr15, 56.57 cM, cytoband F3
• Alliance: Tamalin^tm1.1Tes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181614
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT- and loxP-flanked neo cassette was inserted downstream of exon 1. Cre-mediated recombination removed the neo cassette. Western blot analysis confirmed the absence of protein expression in the hippocampus. (J:181614)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tamalin Mutation: 15 strains or lines available

References

• Original: J:181614 Yanpallewar SU, et al., Tamalin is a critical mediator of electroconvulsive shock-induced adult neuroplasticity. J Neurosci. 2012 Feb 15;32(7):2252-62
• All: 3 reference(s)