Gt(ROSA)26Sor^{tm1(Thy1-FBXL2)Wata}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Thy1-FBXL2)Wata}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Tomomichi Watanabe
• MGI ID: MGI:5318566
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Thy1-FBXL2)Wata} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182731
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Thy1-FBXL2)Wata} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FBXL2 (25827)

  Fbxl2

  (MGI:1919429)

• Mutation details: The expression cassette was knocked into the locus. This vector contains a splice acceptor, ATG start codon, neo cassette, polyadenylation sequence, 5' Thy1 promoter region, human open reading frame, and 3' Thy1 promoter region. (J:182731)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:182731 Watanabe T, et al., FBL2 regulates amyloid precursor protein (APP) metabolism by promoting ubiquitination-dependent APP degradation and inhibition of APP endocytosis. J Neurosci. 2012 Mar 7;32(10):3352-65
• All: 1 reference(s)