Tph2^tm1Mscl
Targeted Allele Detail

Summary

• Symbol: Tph2^tm1Mscl
• Name: tryptophan hydroxylase 2; targeted mutation 1, Michael S Clark
• MGI ID: MGI:5318587
• Synonyms: Tph2^lox
• Gene: Tph2 Location: Chr10:114914546-115020927 bp, - strand Genetic Position: Chr10, 63.51 cM
• Alliance: Tph2^tm1Mscl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182577
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• The first exon was flanked with loxP sites. (J:182577)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tph2 Mutation: 43 strains or lines available

References

• Original: J:182577 Wu Q, et al., Deciphering a neuronal circuit that mediates appetite. Nature. 2012 Mar 29;483(7391):594-7
• All: 4 reference(s)