Mcoln3^tm1.1Hels
Targeted Allele Detail

Summary

• Symbol: Mcoln3^tm1.1Hels
• Name: mucolipin 3; targeted mutation 1.1, Stefan Heller
• MGI ID: MGI:5319089
• Synonyms: Trpml3^flox
• Gene: Mcoln3 Location: Chr3:145823205-145847561 bp, + strand Genetic Position: Chr3, 71.03 cM
• Alliance: Mcoln3^tm1.1Hels page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167711
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 11, and an additional loxP site was inserted downstream of exon 11. Flp-mediated recombination in ES cells removed the neo cassette, creating the floxed allele. (J:167711)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mcoln3 Mutation: 35 strains or lines available

References

• Original: J:167711 Jors S, et al., Genetic inactivation of Trpml3 does not lead to hearing and vestibular impairment in mice. PLoS One. 2010;5(12):e14317
• All: 2 reference(s)