Tigar^tm1.2Smat
Targeted Allele Detail

Summary

• Symbol: Tigar^tm1.2Smat
• Name: Trp53 induced glycolysis regulatory phosphatase; targeted mutation 1.2, Satoaki Matoba
• MGI ID: MGI:5319187
• Gene: Tigar Location: Chr6:127062079-127086520 bp, - strand Genetic Position: Chr6, 61.92 cM
• Alliance: Tigar^tm1.2Smat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183674
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exon 2. Western blot analysis confirmed the absence of protein expression in the heart. (J:183674)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tigar Mutation: 58 strains or lines available

References

• Original: J:183674 Hoshino A, et al., p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia. J Mol Cell Cardiol. 2012 Jan;52(1):175-84
• All: 2 reference(s)