Tg(Myh6-FKBP1A)4Shou
Transgene Detail

Summary

• Symbol: Tg(Myh6-FKBP1A)4Shou
• Name: transgene insertion 4, Weinian Shou
• MGI ID: MGI:5319192
• Synonyms: alphaMyHC-FKBP12
• Transgene: Tg(Myh6-FKBP1A)4Shou Location: unknown
• Alliance: Tg(Myh6-FKBP1A)4Shou page

Transgene origin

• Strain of Origin: C3HeB/FeJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-FKBP1A)4Shou expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FKBP1A (2280)

  Fkbp1a

  (MGI:95541)

• Mutation details: The alpha myosin heavy chain promoter drives expression of a flag tagged human FKBP1A cDNA. Three transgenic lines were generated; 4, 9 and 12. Protein expression is elevated about 9 fold in the heart in all 3 transgenic lines. (J:183588)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:183588 Maruyama M, et al., FKBP12 is a critical regulator of the heart rhythm and the cardiac voltage-gated sodium current in mice. Circ Res. 2011 Apr 29;108(9):1042-52
• All: 2 reference(s)