Fkbp1a^tm1.1Shou
Targeted Allele Detail

Summary

• Symbol: Fkbp1a^tm1.1Shou
• Name: FK506 binding protein 1a; targeted mutation 1.1, Weinian Shou
• MGI ID: MGI:5319193
• Synonyms: FKBP12^flox
• Gene: Fkbp1a Location: Chr2:151384403-151403611 bp, + strand Genetic Position: Chr2, 74.83 cM
• Alliance: Fkbp1a^tm1.1Shou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183588
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed pgk-neo cassette was inserted upstream of exon 3 and a loxP site was inserted downstream of exon 3 via homologous recombination. Cre mediated recombination removed the neo cassette leaving exon 3 floxed. (J:183588)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fkbp1a Mutation: 14 strains or lines available

References

• Original: J:183588 Maruyama M, et al., FKBP12 is a critical regulator of the heart rhythm and the cardiac voltage-gated sodium current in mice. Circ Res. 2011 Apr 29;108(9):1042-52
• All: 2 reference(s)