Fbxo4^tm1Kei
Targeted Allele Detail

Summary

• Symbol: Fbxo4^tm1Kei
• Name: F-box protein 4; targeted mutation 1, Keiichi I Nakayama
• MGI ID: MGI:5319202
• Gene: Fbxo4 Location: Chr15:3994927-4009055 bp, - strand Genetic Position: Chr15, 1.84 cM, cytoband A1
• Alliance: Fbxo4^tm1Kei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183656
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ/neo cassette replaced exon 1 (downstream of the translation initiation site) through exon 5. RT-PCR confirmed the absence of transcript expression in mouse embryonic fibroblasts. (J:183656)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fbxo4 Mutation: 25 strains or lines available

References

• Original: J:183656 Kanie T, et al., Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation. Mol Cell Biol. 2012 Feb;32(3):590-605
• All: 1 reference(s)