Cdk16^tm1.2Stge
Targeted Allele Detail

Summary

• Symbol: Cdk16^tm1.2Stge
• Name: cyclin dependent kinase 16; targeted mutation 1.2, Stephen Geley
• MGI ID: MGI:5319210
• Synonyms: Cdk16^delta
• Gene: Cdk16 Location: ChrX:20554210-20566119 bp, + strand Genetic Position: ChrX, 16.18 cM
• Alliance: Cdk16^tm1.2Stge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183637
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exons 7 through 14 from Cdk16^tm1.1Stge. Western blot analysis confirmed the absence of protein expression in the brain and testis. (J:183637)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk16 Mutation: 10 strains or lines available

References

• Original: J:183637 Mikolcevic P, et al., Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis. Mol Cell Biol. 2012 Feb;32(4):868-79
• All: 2 reference(s)