Tle3^tm1Jcc
Targeted Allele Detail

Summary

• Symbol: Tle3^tm1Jcc
• Name: transducin-like enhancer of split 3; targeted mutation 1, James C Cross
• MGI ID: MGI:5319211
• Gene: Tle3 Location: Chr9:61279665-61325772 bp, + strand Genetic Position: Chr9, 33.27 cM, cytoband C
• Alliance: Tle3^tm1Jcc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183486
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing a IRES lacZ reporter construct and neomycin resistance gene was inserted in exon 1 via homologous recombination. Western blot analysis confirmed the absence of protein expression in E12.5 embryos. (J:183486, J:202343)

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tle3 Mutation: 47 strains or lines available

References

• Original: J:183486 Metzger DE, et al., The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and beta-cell differentiation. Development. 2012 Apr;139(8):1447-56
• All: 3 reference(s)