Pink1^tm1Vbae
Targeted Allele Detail

Summary

• Symbol: Pink1^tm1Vbae
• Name: PTEN induced putative kinase 1; targeted mutation 1, Veerle Baekelandt
• MGI ID: MGI:5319215
• Gene: Pink1 Location: Chr4:138040720-138053618 bp, - strand Genetic Position: Chr4, 70.14 cM
• Alliance: Pink1^tm1Vbae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182977
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exon 1. RT-PCR confirmed the absence of transcript expression in the brain and mouse embryonic fibroblasts. (J:182977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pink1 Mutation: 43 strains or lines available

References

• Original: J:182977 Heeman B, et al., Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance. J Cell Sci. 2011 Apr 1;124(Pt 7):1115-25
• All: 3 reference(s)