Ptpn1^tm1.1Kry
Targeted Allele Detail

Summary

• Symbol: Ptpn1^tm1.1Kry
• Name: protein tyrosine phosphatase, non-receptor type 1; targeted mutation 1.1, Gerard Karsenty
• MGI ID: MGI:5319223
• Synonyms: Ptpn1^fl
• Gene: Ptpn1 Location: Chr2:167773977-167821305 bp, + strand Genetic Position: Chr2, 87.99 cM, cytoband H3
• Alliance: Ptpn1^tm1.1Kry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183709
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 6. An FRT-flanked neo cassette with a 3' loxP site were inserted downstream of exon 8. Flp-mediated recombination removed the neo cassette and left exons 6 through 8 floxed. (J:183709)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn1 Mutation: 36 strains or lines available

References

• Original: J:183709 Zee T, et al., T-cell protein tyrosine phosphatase regulates bone resorption and whole-body insulin sensitivity through its expression in osteoblasts. Mol Cell Biol. 2012 Mar;32(6):1080-8
• All: 1 reference(s)