Tg(Myh6-MYPN*Y20C)#Jato
Transgene Detail

Summary

• Symbol: Tg(Myh6-MYPN*Y20C)#Jato
• Name: transgene insertion, Jeffrey A Towbin
• MGI ID: MGI:5319508
• Synonyms: MYPN^Y20C
• Transgene: Tg(Myh6-MYPN*Y20C)#Jato Location: unknown
• Alliance: Tg(Myh6-MYPN*Y20C)#Jato page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-MYPN*Y20C)#Jato expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYPN (84665)

  Mypn	(MGI:1916052)

  Transgene codes for a protein with a tyrosine to cysteine mutation.

• Mutation details: This transgene expresses the human MYPN cDNA containing a Y20C mutation under the control of the mouse alpha myosin heavy chain promoter resulting in cardiac-restricted overexpression of the transgene. Two founders were made, however line numbers are not specified. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:181871)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:181871 Purevjav E, et al., Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations. Hum Mol Genet. 2012 May 1;21(9):2039-53
• All: 2 reference(s)