Ago1^tm1.1Tara
Targeted Allele Detail

Summary

• Symbol: Ago1^tm1.1Tara
• Name: argonaute RISC catalytic subunit 1; targeted mutation 1.1, Alexander Tarakhovsky
• MGI ID: MGI:5319524
• Synonyms: Ago1^fl
• Gene: Ago1 Location: Chr4:126328805-126362376 bp, - strand Genetic Position: Chr4, 60.76 cM
• Alliance: Ago1^tm1.1Tara page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183622
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector containing FRT site flanked NEO cassette and 2 loxP sites that was used to flank exons 13-16 with loxP sites. Flp-mediated recombination removed the neo cassette and left exons 13 through 16 floxed. (J:188988)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ago1 Mutation: 160 strains or lines available

References

• Original: J:183622 Wang D, et al., Quantitative functions of Argonaute proteins in mammalian development. Genes Dev. 2012 Apr 1;26(7):693-704
• All: 5 reference(s)