Ppargc1a^tm1.1Javi
Targeted Allele Detail

Summary

• Symbol: Ppargc1a^tm1.1Javi
• Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; targeted mutation 1.1, Josep A Villena
• MGI ID: MGI:5319541
• Gene: Ppargc1a Location: Chr5:51611592-51725068 bp, - strand Genetic Position: Chr5, 27.02 cM, cytoband C1
• Alliance: Ppargc1a^tm1.1Javi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180984
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4 and an FRT flanked pgk-neo cassette and loxP site were inserted downstream of exon 5 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:180984)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppargc1a Mutation: 48 strains or lines available

References

• Original: J:180984 Pardo R, et al., Rosiglitazone-induced mitochondrial biogenesis in white adipose tissue is independent of peroxisome proliferator-activated receptor gamma coactivator-1alpha. PLoS One. 2011;6(11):e26989
• All: 3 reference(s)