Tg(NPHS2-Trpc6*P111Q)F615Walz
Transgene Detail
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Symbol: |
Tg(NPHS2-Trpc6*P111Q)F615Walz |
Name: |
transgene insertion F615, Katherina Walz |
MGI ID: |
MGI:5319638 |
Synonyms: |
Trpc6-HA P111Q |
Transgene: |
Tg(NPHS2-Trpc6*P111Q)F615Walz Location: unknown
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Alliance: |
Tg(NPHS2-Trpc6*P111Q)F615Walz page
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Strain of Origin: |
C57BL/6J x CBA/J
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(NPHS2-Trpc6*P111Q)F615Walz expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Trpc6 (MGI:109523) |
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Mutation details: The Trpc6-HA wildtype cDNA sequence was made by modifying a Trpc6 cDNA sequence (encoding a 930 amino acid protein) originally isolated from mouse brain tissue by both repairing an A2615G point mutation (D872G) and also by in-frame addition of an influenza virus hemaglutinin epitope (HA-tag) at the 3' end. The cDNA sequence was placed downstream of a 2.5 kbp fragment from the promoter/enhancer region of the human podocin locus (NPHS2) and upstream from a bovine growth hormone polyA sequence. The C332A nucleotide substitution was introduced to produce the amino acid substitution of glutamine for proline at position 111 (P111Q). Lines F615 and F615 were generated.
(J:165112)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:165112 Krall P, et al., Podocyte-specific overexpression of wild type or mutant trpc6 in mice is sufficient to cause glomerular disease. PLoS One. 2010;5(9):e12859 |
All: |
1 reference(s) |
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