Mir21a^tm1.1Sho
Targeted Allele Detail

Summary

• Symbol: Mir21a^tm1.1Sho
• Name: microRNA 21a; targeted mutation 1.1, Stuart H Orkin
• MGI ID: MGI:5319685
• Gene: Mir21a Location: Chr11:86474893-86474984 bp, - strand Genetic Position: Chr11, 51.82 cM
• Alliance: Mir21a^tm1.1Sho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183786
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the sequence and an FRT flanked neo cassette and loxP site were inserted downstream of the sequence via homologous recombination. Cre mediated recombination removed the sequence and the neo cassette. RNA analysis confirmed the absence of expression in homozygous mice. Northern blot analysis confirmed expression of Vmp1. (J:183786)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir21a Mutation: 8 strains or lines available

References

• Original: J:183786 Chau BN, et al., MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. Sci Transl Med. 2012 Feb 15;4(121):121ra18
• All: 3 reference(s)