Isl1^tm2.1Sev
Targeted Allele Detail

Summary

• Symbol: Isl1^tm2.1Sev
• Name: ISL1 transcription factor, LIM/homeodomain; targeted mutation 2.1, Sylvia M Evans
• MGI ID: MGI:5320481
• Gene: Isl1 Location: Chr13:116434817-116446225 bp, - strand Genetic Position: Chr13, 64.87 cM, cytoband D2.3
• Alliance: Isl1^tm2.1Sev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184018
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4, which encodes the homeodomain of the protein product, was floxed by the insertion of a loxP site on one end and a loxP site and frt-flanked neo cassette on the other end. Recombinase-mediated recombination of This allele was used to generate Isl1^tm4Sev removed the neo cassette and exon 4. (J:141110)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Isl1 Mutation: 36 strains or lines available

References

• Original: J:184018 Itou J, et al., Islet1 regulates establishment of the posterior hindlimb field upstream of the Hand2-Shh morphoregulatory gene network in mouse embryos. Development. 2012 May;139(9):1620-9
• All: 3 reference(s)