Zbtb46^tm1Kmm
Targeted Allele Detail

Summary

• Symbol: Zbtb46^tm1Kmm
• Name: zinc finger and BTB domain containing 46; targeted mutation 1, Kenneth Murphy
• MGI ID: MGI:5320483
• Synonyms: Zbtb46^gfp
• Gene: Zbtb46 Location: Chr2:181029555-181101219 bp, - strand Genetic Position: Chr2, 103.63 cM, cytoband H4
• Alliance: Zbtb46^tm1Kmm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184205
• Parent Cell Line: EDJ22 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: A targeting vector was designed to replace exon 2, which encodes the start codon and the BTB domain of the zinc finger and BTB domain, with an enhanced green fluorescent protein followed by a polyadenylation signal and a floxed neo cassette. Microarray analysis confirmed the absence of transcript expression in dendritic cells. (J:184205)

Generation of the Zbtb46^tm1Kmm allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zbtb46 Mutation: 36 strains or lines available

References

• Original: J:184205 Satpathy AT, et al., Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages. J Exp Med. 2012 Jun 4;209(6):1135-52
• All: 17 reference(s)