Hk2^tm1.1Uku
Targeted Allele Detail

Summary

• Symbol: Hk2^tm1.1Uku
• Name: hexokinase 2; targeted mutation 1.1, University of Kuopio
• MGI ID: MGI:5320615
• Synonyms: Hk2lox, neoless Hk2lox, Neoless Oy1109B
• Gene: Hk2 Location: Chr6:82702006-82751435 bp, - strand Genetic Position: Chr6, 35.94 cM
• Alliance: Hk2^tm1.1Uku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82809
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP-flanked neomycin resistance (neo) cassette was inserted into intron 3 and a third loxP site into intron 10. The neo cassette was deleted by Cre recombinase in vivo, leaving a single loxP site in intron 3. Crossing mice with this allele to animals expressing Cre recombinase will result in deletion of exons 4-10, inactivating the gene, in the offpring in the tissues or cell types where Cre is expressed. (J:82809)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hk2 Mutation: 60 strains or lines available

References

• Original: J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013
• All: 11 reference(s)